Optimizing an Injectable Composite Oxygen-Generating System for Relieving Tissue Hypoxia

Optimizing an Injectable Composite Oxygen-Generating System for Relieving Tissue Hypoxia

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Oxygen deficiency resulting from bone fracture-induced vascular disruption leads to massive cell death and delayed osteoblast differentiation, ultimately impairing new bone formation and 5 Piece Counter Height Dining Set fracture healing.Enhancing local tissue oxygenation can help promote bone regeneration.In this work, an injectable composite oxygen-generating system consisting of calcium peroxide (CaO2)/manganese dioxide (MnO2)-encapsulated poly lactic-co-glycolic acid (PLGA) microparticles (CaO2 + MnO2@PLGA MPs) is proposed for the local delivery of oxygen.By utilizing a series of methodologies, the impacts of each component used for MP fabrication on the oxygen release behavior and cytotoxicity of the CaO2 + MnO2@ PLGA MPs are thoroughly investigated.

Our analytical data obtained from in vitro studies indicate that the optimized CaO2 + MnO2@PLGA MPs developed in this study can effectively relieve the hypoxia of preosteoblast MC3T3-E1 cells that are grown under low oxygen tension and Bread promote their osteogenic differentiation, thus holding great promise in enhancing fractural healing by increasing tissue oxygenation.